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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-182
ncRNA name hsa-miR-182
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples, normal retinas; RB cell lines Y79 and WERI-RB1
Methods luciferase reporter assay, transfection, qRT-PCR, Western blot, MTT assay, transwell assay, xenograft, immunohistochemistry
Expression pattern up-regulated
Functional description Inhibition of miR‑182 may suppress cell viability, invasion and angiogenesis in RB through inactivation of the PI3K/AKT pathway and CADM2 upregulation.
PubMed ID 30320366
Year 2018
Title Downregulation of microRNA‑182 inhibits cell viability, invasion and angiogenesis in retinoblastoma through inhibition of the PI3K/AKT pathway and CADM2 upregulation.
Drug-related ncRNA NO

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